"CD4-positive or CD8-positive, alpha-beta T cell lineage commitment"

Across TCGA cell cohorts, RNA activity of the "CD4-positive or CD8-positive, alpha-beta T cell lineage commitment" pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTSL, TNFAIP8L1, and HS1BP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "CD4-positive or CD8-positive, alpha-beta T cell lineage commitment" activity versus CTSL in LUNG_NSCLC_LUAD (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CTSL →	+2.107	+1.145	<.001	<.001	3	5
BLOOD_Myeloma	TNFAIP8L1 →	-0.927	-1.632	.001	.001	3	4
CNS	HS1BP3 →	+0.790	+0.899	<.001	.003	3	4
LUNG_NSCLC_LUAD	LYAR →	-0.815	-1.004	<.001	.001	3	4
BLOOD_Leukemia	SRGN →	+3.570	+0.164	.002	.003	3	4
BLOOD_Leukemia	RAPGEF5 →	-1.340	-0.142	.006	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043369 vs CTSL — LUNG_NSCLC_LUAD

Explore this scatter interactively →