Positive T cell selection

Across TCGA patient cohorts, RNA activity of the Positive T cell selection pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRTAM, IL10RA, and CYTIP, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive T cell selection activity versus CRTAM in LUAD (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CRTAM →	+0.730	+0.235	<.001	.004	3	9
LSCC	IL10RA →	+0.690	+0.498	.003	.001	3	9
BRCA	CYTIP →	+1.096	+0.797	<.001	<.001	3	9
BRCA	SLAMF1 →	+0.894	+0.682	<.001	<.001	3	9
BRCA	CD48 →	+0.829	+0.624	<.001	<.001	3	9
BRCA	ARHGAP9 →	+0.685	+0.657	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043368 vs CRTAM — LUAD

Explore this scatter interactively →