Positive T cell selection

Across TCGA cell cohorts, RNA activity of the Positive T cell selection pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHKA1, CASP8AP2, and DHX9, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PHKA1 grouped by Positive T cell selection-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PHKA1 →	+0.134	+0.986	<.001	.003	3	3
PANCREAS	CASP8AP2 →	+0.432	+0.865	.001	.002	3	3
PANCREAS	DHX9 →	+0.345	+1.275	.001	.007	3	3
LUNG_NSCLC_LUAD	PTPRR →	-0.202	-1.247	.009	.008	3	3
LUNG_NSCLC_LUSC	UVRAG →	+0.144	+2.031	<.001	<.001	3	3
OVARY	CDH22 →	-0.226	-0.449	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PHKA1 by Positive T cell selection activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →