Positive T cell selection

Across TCGA cell cohorts, RNA activity of the Positive T cell selection pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTSL, WDR43, and DNAL4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive T cell selection activity versus CTSL in LUNG_NSCLC_LUAD (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CTSL →	+2.107	+1.145	<.001	<.001	3	5
OVARY	WDR43 →	-0.990	-1.095	<.001	.006	3	4
BLOOD_Leukemia	DNAL4 →	+0.593	+0.221	.008	<.001	3	4
LUNG_NSCLC_LUAD	LYAR →	-0.815	-1.004	<.001	.001	3	4
KIDNEY	TENT5A →	+1.708	+1.364	.005	.008	3	3
CNS	HS1BP3 →	+0.614	+0.672	.003	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043368 vs CTSL — LUNG_NSCLC_LUAD

Explore this scatter interactively →