"CD4-positive, alpha-beta T cell differentiation"

Across TCGA patient cohorts, RNA activity of the "CD4-positive, alpha-beta T cell differentiation" pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP9, DOK3, and WAS, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "CD4-positive, alpha-beta T cell differentiation" activity versus ARHGAP9 in GBM (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ARHGAP9 →	+0.876	+0.613	<.001	<.001	3	7
UCEC	DOK3 →	+0.793	+0.444	<.001	<.001	3	7
GBM	WAS →	+0.820	+0.509	<.001	<.001	3	7
HNSC	MEFV →	+1.009	+0.608	<.001	.001	3	7
GBM	LCP2 →	+0.987	+0.460	<.001	<.001	3	7
LSCC	CD7 →	+0.663	+0.634	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043367 vs ARHGAP9 — GBM

Explore this scatter interactively →