"CD4-positive, alpha-beta T cell differentiation"

Across TCGA cell cohorts, RNA activity of the "CD4-positive, alpha-beta T cell differentiation" pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GTF2IRD1, PPIG, and RORA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GTF2IRD1 grouped by "CD4-positive, alpha-beta T cell differentiation"-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GTF2IRD1 →	-0.270	-0.731	<.001	.005	3	4
KIDNEY	PPIG →	-0.244	-1.203	.006	.002	3	4
UPPER_AERODIGESTIVE_TRACT	RORA →	-0.255	-1.181	<.001	.005	2	5
SKIN	NINJ2 →	-0.202	-0.809	.004	.006	3	3
SKIN	KCNA4 →	-0.123	-0.644	.002	.003	3	3
SKIN	LINC01205 →	+0.110	+0.628	.006	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GTF2IRD1 by "CD4-positive, alpha-beta T cell differentiation" activity — CNS

Explore this box plot interactively →