"CD4-positive, alpha-beta T cell differentiation"

Across TCGA cell cohorts, RNA activity of the "CD4-positive, alpha-beta T cell differentiation" pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COX11, NME6, and LPP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COX11 grouped by "CD4-positive, alpha-beta T cell differentiation"-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	COX11 →	-0.273	-0.091	.008	.003	3	5
LIVER	NME6 →	-0.225	-0.118	<.001	.003	3	5
LUNG_SCLC	LPP →	+0.305	+0.086	.006	.004	3	5
LUNG_NSCLC_LUSC	LGSN →	+0.206	+0.131	<.001	.007	3	5
CNS	TKTL1 →	-0.231	-0.075	<.001	<.001	3	5
LUNG_SCLC	CDK13 →	-0.288	-0.134	.007	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COX11 by "CD4-positive, alpha-beta T cell differentiation" activity — BREAST

Explore this box plot interactively →