"CD4-positive, alpha-beta T cell differentiation"

Across TCGA cell cohorts, RNA activity of the "CD4-positive, alpha-beta T cell differentiation" pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL6ST, OSBPL2, and ATP6V0E2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "CD4-positive, alpha-beta T cell differentiation" activity versus IL6ST in BREAST (Pearson r = -0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	IL6ST →	-1.613	-0.325	.001	.002	3	6
OVARY	OSBPL2 →	-0.848	-0.343	.005	.008	3	6
UPPER_AERODIGESTIVE_TRACT	ATP6V0E2 →	+1.557	+0.783	<.001	.008	3	6
BONE	RCOR2 →	+1.855	+0.429	.003	.007	3	6
LIVER	CLUH →	+0.851	+0.418	.005	<.001	3	6
LARGE_INTESTINE	METTL21A →	+0.722	+0.351	.006	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043367 vs IL6ST — BREAST

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