Protein unfolding

Across TCGA patient cohorts, RNA activity of the Protein unfolding pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HIP1, ZKSCAN1, and PEX1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein unfolding activity versus HIP1 in CCRCC (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	HIP1 →	+0.266	+0.058	<.001	<.001	3	6
HNSC	ZKSCAN1 →	+0.323	+0.084	.001	.001	3	5
HNSC	PEX1 →	+0.268	+0.071	<.001	<.001	3	5
LSCC	PEX6 →	+0.299	+0.073	<.001	<.001	3	5
OV	LAMA4 →	+0.601	+0.054	.006	.001	3	5
BRCA	ANGPTL4 →	+0.769	+0.042	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043335 vs HIP1 — CCRCC

Explore this scatter interactively →