Protein unfolding

Across TCGA cell cohorts, RNA activity of the Protein unfolding pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STOML2, VCP, and DDN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STOML2 grouped by Protein unfolding-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	STOML2 →	-0.772	-0.407	.006	.008	3	6
KIDNEY	VCP →	-0.977	-0.320	.004	<.001	3	5
LIVER	DDN →	-0.698	-0.231	<.001	<.001	3	4
BREAST	MRPL48 →	-0.671	-0.232	.001	.002	3	4
BLOOD_Myeloma	TTK →	-1.467	-0.274	.002	.001	3	4
BLOOD_Myeloma	MAP3K7 →	-0.973	-0.259	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STOML2 by Protein unfolding activity — BONE

Explore this box plot interactively →