Response to dsRNA

Across TCGA patient cohorts, RNA activity of the Response to dsRNA pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NMI, MX2, and DDX60, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to dsRNA activity versus NMI in LUAD (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NMI →	+0.411	+0.047	<.001	<.001	3	10
HNSC	MX2 →	+0.696	+0.045	<.001	.007	3	8
HNSC	DDX60 →	+0.530	+0.046	<.001	.006	3	8
LUAD	IFI35 →	+0.392	+0.056	<.001	<.001	3	8
HNSC	IFIT1 →	+0.870	+0.066	<.001	.003	3	8
HNSC	IFIT2 →	+0.915	+0.058	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043331 vs NMI — LUAD

Explore this scatter interactively →