Response to dsRNA

Across TCGA patient cohorts, RNA activity of the Response to dsRNA pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAP2, IL2RG, and AIM2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to dsRNA activity versus TAP2 in BRCA (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TAP2 →	+1.018	+0.318	<.001	<.001	3	7
BRCA	IL2RG →	+0.766	+0.186	.005	.008	3	6
BRCA	AIM2 →	+0.981	+0.211	.002	.001	3	6
BRCA	GBP5 →	+1.405	+0.266	<.001	<.001	3	6
CCRCC	CXCR2P1 →	+1.012	+0.157	.004	.003	3	6
BRCA	CXCL11 →	+1.188	+0.248	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043331 vs TAP2 — BRCA

Explore this scatter interactively →