Response to dsRNA

Across TCGA cell cohorts, RNA activity of the Response to dsRNA pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PODNL1, MPO, and MR1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PODNL1 grouped by Response to dsRNA-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PODNL1 →	+1.758	+1.180	.002	<.001	3	4
KIDNEY	MPO →	+0.469	+0.766	<.001	.006	3	3
SOFT_TISSUE	MR1 →	+2.255	+1.509	<.001	<.001	3	3
SOFT_TISSUE	RFX7 →	+0.834	+1.141	<.001	.001	3	3
BONE	GPR180 →	+0.573	+0.311	.005	.004	2	3
OVARY	USP9X →	+0.690	+0.692	.007	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PODNL1 by Response to dsRNA activity — SOFT_TISSUE

Explore this box plot interactively →