Response to dsRNA

Across TCGA cell cohorts, RNA activity of the Response to dsRNA pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MVP, SBNO2, and AIDA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to dsRNA activity versus MVP in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MVP →	-1.800	-0.179	.006	.002	3	6
UPPER_AERODIGESTIVE_TRACT	SBNO2 →	-1.996	-0.160	.007	.006	3	5
SKIN	AIDA →	-0.542	-0.130	<.001	<.001	3	5
URINARY_TRACT	ZNF75D →	-0.603	-0.257	.002	<.001	3	5
LUNG_NSCLC_LUSC	PDXK →	-1.151	-0.187	.006	.007	3	5
CNS	CAMK2G →	-0.538	-0.131	.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043331 vs MVP — UPPER_AERODIGESTIVE_TRACT

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