Natural killer cell degranulation

Across TCGA patient cohorts, RNA activity of the Natural killer cell degranulation pathway is significantly associated with the RNA expression of multiple genes, with the BLCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYTH4, IL2RB, and HCK, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Natural killer cell degranulation activity versus CYTH4 in BLCA (Pearson r = 0.83).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	CYTH4 →	+1.789	+0.126	<.001	<.001	3	34
SKCM	IL2RB →	+2.416	+0.130	<.001	<.001	3	34
BLCA	HCK →	+2.124	+0.122	<.001	<.001	3	34
DLBC	LILRB1 →	+1.786	+0.114	<.001	.001	3	34
SKCM	CRTAM →	+1.695	+0.132	<.001	<.001	3	34
BLCA	MS4A6A →	+2.056	+0.124	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043320 vs CYTH4 — BLCA

Explore this scatter interactively →