Natural killer cell degranulation

Across TCGA patient cohorts, RNA activity of the Natural killer cell degranulation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GBP5, NKG7, and GBP4, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Natural killer cell degranulation activity versus GBP5 in UCEC (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GBP5 →	+1.328	+0.216	<.001	<.001	3	10
GBM	NKG7 →	+1.112	+0.224	<.001	<.001	3	9
LUAD	GBP4 →	+1.090	+0.244	<.001	<.001	3	9
HNSC	BATF2 →	+1.252	+0.232	<.001	<.001	3	9
HNSC	CXCL10 →	+1.629	+0.190	.002	<.001	3	9
HNSC	CXCL11 →	+1.749	+0.177	.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043320 vs GBP5 — UCEC

Explore this scatter interactively →