Natural killer cell degranulation

Across TCGA cell cohorts, RNA activity of the Natural killer cell degranulation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GAB2, SLX1A, and MRPL4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GAB2 grouped by Natural killer cell degranulation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	GAB2 →	+2.075	+1.309	.001	.003	3	4
LUNG_NSCLC_LUAD	SLX1A →	-1.060	-0.812	.001	.003	3	4
PANCREAS	MRPL4 →	-1.313	-1.700	.005	.004	3	3
PANCREAS	MPZL3 →	+1.976	+1.539	.005	.002	3	3
PANCREAS	MEMO1 →	-0.824	-1.532	.007	.009	3	3
PANCREAS	WDR43 →	-0.962	-1.441	.004	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GAB2 by Natural killer cell degranulation activity — LUNG_SCLC

Explore this box plot interactively →