Natural killer cell degranulation

Across TCGA cell cohorts, RNA activity of the Natural killer cell degranulation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CORO1A, VAMP7, and SSR4, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Natural killer cell degranulation activity versus CORO1A in BREAST (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CORO1A →	+3.047	+0.219	<.001	<.001	3	11
BLOOD_Myeloma	VAMP7 →	+1.048	+0.268	<.001	<.001	3	11
LUNG_NSCLC_LUSC	SSR4 →	+0.938	+0.295	.007	.002	3	10
OESOPHAGUS	MCTS1 →	+0.490	+0.151	<.001	.006	3	8
SOFT_TISSUE	MAN2C1 →	-1.066	-0.200	<.001	<.001	3	7
OESOPHAGUS	RPAP1 →	-0.843	-0.162	.001	.005	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043320 vs CORO1A — BREAST

Explore this scatter interactively →