Regulation of neutrophil degranulation

Across TCGA cell cohorts, RNA activity of the Regulation of neutrophil degranulation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASB2, RASSF2, and PTPN6, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neutrophil degranulation activity versus ASB2 in BLOOD_Lymphoma (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ASB2 →	+5.108	+1.381	<.001	.003	3	2
BLOOD_Leukemia	RASSF2 →	+1.984	+1.415	.001	<.001	3	2
BLOOD_Lymphoma	PTPN6 →	+2.593	+1.280	.008	<.001	3	2
BLOOD_Lymphoma	CHD5 →	-0.178	-0.946	.001	.008	3	2
BLOOD_Leukemia	KLF7 →	+1.700	+1.346	<.001	.001	3	2
BLOOD_Lymphoma	NEK6 →	+2.199	+1.164	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043313 vs ASB2 — BLOOD_Lymphoma

Explore this scatter interactively →