Eosinophil activation

Across TCGA cell cohorts, RNA activity of the Eosinophil activation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC38A9, KCTD15, and HELZ, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC38A9 grouped by Eosinophil activation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SLC38A9 →	+0.530	+1.120	<.001	<.001	3	5
SKIN	KCTD15 →	-0.759	-1.134	.001	.001	3	4
SKIN	HELZ →	-0.627	-0.889	.002	.003	3	4
BLOOD_Myeloma	RBM7 →	+0.705	+1.709	.006	<.001	3	4
LUNG_NSCLC_LUAD	MT2A →	+2.501	+0.813	.001	.006	3	4
LUNG_NSCLC_LUAD	ANKRD28 →	+0.658	+0.930	.008	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC38A9 by Eosinophil activation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →