Eosinophil activation

Across TCGA cell cohorts, RNA activity of the Eosinophil activation pathway is significantly associated with the total protein of multiple features, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are p38-MAPK_pT180_Y182, PKC-a_pS657, and Snail, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Eosinophil activation activity versus p38-MAPK_pT180_Y182 in BLOOD_Myeloma (Pearson r = -0.97).

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	p38-MAPK_pT180_Y182 →	-1.059	-2.258	.003	.013	1	1
BLOOD_Myeloma	PKC-a_pS657 →	-1.981	-2.258	.040	.013	1	1
BLOOD_Myeloma	Snail →	-0.236	-2.258	.006	.013	1	1
BLOOD_Myeloma	B-Raf →	+0.626	+2.258	.038	.013	1	1
BLOOD_Myeloma	Cyclin-B1 →	-1.509	-2.258	.011	.013	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest associations by consensus.

GO:0043307 vs p38-MAPK_pT180_Y182 — BLOOD_Myeloma

Explore this scatter interactively →