Positive regulation of leukocyte degranulation

Across TCGA patient cohorts, RNA activity of the Positive regulation of leukocyte degranulation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WIPF1, ELMO2, and FERMT3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of leukocyte degranulation activity versus WIPF1 in OV (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	WIPF1 →	+0.465	+0.072	<.001	<.001	3	10
COAD	ELMO2 →	+0.286	+0.050	<.001	<.001	3	10
GBM	FERMT3 →	+0.665	+0.109	<.001	<.001	3	10
GBM	ALOX5 →	+0.901	+0.113	<.001	<.001	3	10
UCEC	ITGAX →	+0.717	+0.071	<.001	<.001	3	10
GBM	ITGB2 →	+0.763	+0.102	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043302 vs WIPF1 — OV

Explore this scatter interactively →