Positive regulation of leukocyte degranulation

Across TCGA cell cohorts, RNA activity of the Positive regulation of leukocyte degranulation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZMYM3, NUP37, and UGP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZMYM3 grouped by Positive regulation of leukocyte degranulation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ZMYM3 →	-0.629	-0.809	.006	<.001	3	4
LIVER	NUP37 →	+0.754	+1.538	.004	<.001	3	4
OESOPHAGUS	UGP2 →	+0.538	+0.943	.005	.001	3	4
LUNG_SCLC	MGAT1 →	-1.031	-1.400	.005	<.001	3	4
BONE	TWF2 →	-1.123	-1.244	.004	.003	3	4
SOFT_TISSUE	MYL9 →	-5.898	-1.827	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZMYM3 by Positive regulation of leukocyte degranulation activity — BREAST

Explore this box plot interactively →