Positive regulation of leukocyte degranulation

Across TCGA cell cohorts, RNA activity of the Positive regulation of leukocyte degranulation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL12, ZNF232, and STIM2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of leukocyte degranulation activity versus RPL12 in OESOPHAGUS (Pearson r = -0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	RPL12 →	-0.851	-0.169	<.001	.002	3	6
BLOOD_Leukemia	ZNF232 →	-1.204	-0.520	<.001	.001	3	5
BLOOD_Leukemia	STIM2 →	-1.186	-0.558	.001	.005	3	5
OESOPHAGUS	RPS27A →	-0.664	-0.174	<.001	.001	3	4
STOMACH	CHST11 →	+2.516	+0.258	.002	.003	3	4
BLOOD_Leukemia	TMEM105 →	+2.687	+0.557	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043302 vs RPL12 — OESOPHAGUS

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