Negative regulation of leukocyte degranulation

Across TCGA cell cohorts, RNA activity of the Negative regulation of leukocyte degranulation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DOK2, GNL1, and ITPRIPL2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of leukocyte degranulation activity versus DOK2 in BLOOD_Leukemia (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DOK2 →	+2.043	+0.693	<.001	.003	3	3
BLOOD_Leukemia	GNL1 →	-0.870	-1.000	<.001	.007	3	2
BLOOD_Leukemia	ITPRIPL2 →	+0.775	+0.873	.007	<.001	3	2
BLOOD_Leukemia	SMIM13 →	-0.602	-0.974	<.001	<.001	3	2
BLOOD_Leukemia	EED →	-0.499	-0.713	.001	.002	3	2
BLOOD_Leukemia	NUP155 →	-0.537	-0.800	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043301 vs DOK2 — BLOOD_Leukemia

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