Regulation of leukocyte degranulation

Across TCGA cell cohorts, RNA activity of the Regulation of leukocyte degranulation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRIPT, TSR2, and PPME1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CRIPT grouped by Regulation of leukocyte degranulation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CRIPT →	-0.504	-0.950	.002	.002	3	5
LIVER	TSR2 →	+0.930	+1.427	.001	<.001	3	4
CNS	PPME1 →	-1.104	-0.851	<.001	.003	3	4
BONE	CD151 →	-1.254	-1.096	.007	.008	3	4
LUNG_NSCLC_LUAD	ADPRS →	-0.720	-0.814	<.001	.002	3	4
LUNG_NSCLC_LUAD	MS4A3 →	+0.043	+0.562	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CRIPT by Regulation of leukocyte degranulation activity — LARGE_INTESTINE

Explore this box plot interactively →