Regulation of leukocyte degranulation

Across TCGA cell cohorts, RNA activity of the Regulation of leukocyte degranulation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1orf216, TOLLIP, and CPEB2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of leukocyte degranulation activity versus C1orf216 in SKIN (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	C1orf216 →	+0.637	+0.155	.003	.009	3	6
PANCREAS	TOLLIP →	+0.851	+0.215	.001	.007	3	5
BLOOD_Myeloma	CPEB2 →	+1.235	+0.241	.004	.004	3	5
LUNG_SCLC	ATP6V1D →	+0.881	+0.253	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	C9orf85 →	-0.576	-0.245	.002	.006	3	4
SKIN	FNIP2 →	+1.239	+0.240	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043300 vs C1orf216 — SKIN

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