Leukocyte degranulation

Across TCGA patient cohorts, RNA activity of the Leukocyte degranulation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SAMSN1, CSF3R, and CCRL2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Leukocyte degranulation activity versus SAMSN1 in LSCC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SAMSN1 →	+0.985	+0.430	<.001	<.001	3	9
UCEC	CSF3R →	+1.403	+0.480	<.001	<.001	3	8
GBM	CCRL2 →	+0.882	+0.317	<.001	<.001	3	8
HNSC	LILRB2 →	+0.773	+0.260	.003	<.001	3	8
GBM	STX11 →	+0.542	+0.198	<.001	.002	3	8
HNSC	ITGAX →	+0.883	+0.469	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043299 vs SAMSN1 — LSCC

Explore this scatter interactively →