Leukocyte degranulation

Across TCGA cell cohorts, RNA activity of the Leukocyte degranulation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H2BC4, MKNK1, and H2BC10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, H2BC4 grouped by Leukocyte degranulation-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	H2BC4 →	-1.039	-1.016	.005	.007	3	3
BREAST	MKNK1 →	-0.626	-0.737	.008	.005	2	4
KIDNEY	H2BC10 →	-0.346	-1.078	.001	.001	3	3
BLOOD_Leukemia	ADCY7 →	-2.310	-1.193	.003	.003	3	3
BLOOD_Leukemia	RETREG1 →	+2.129	+1.310	.002	.005	3	3
BLOOD_Myeloma	ETFRF1 →	-1.855	-1.701	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

H2BC4 by Leukocyte degranulation activity — LIVER

Explore this box plot interactively →