Apical junction assembly

Across TCGA cell cohorts, RNA activity of the Apical junction assembly pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZEB1, LIMK1, and ASL, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Apical junction assembly activity versus ZEB1 in URINARY_TRACT (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ZEB1 →	+3.352	+0.314	<.001	.002	3	6
BONE	LIMK1 →	+1.011	+0.190	<.001	.001	3	5
BLOOD_Leukemia	ASL →	+1.575	+0.236	<.001	<.001	3	5
LARGE_INTESTINE	NUDT16 →	+0.678	+0.241	<.001	<.001	3	5
URINARY_TRACT	OVOL2 →	-3.012	-0.416	<.001	.004	3	5
LUNG_NSCLC_LUSC	EMP3 →	+5.360	+0.296	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043297 vs ZEB1 — URINARY_TRACT

Explore this scatter interactively →