Apical junction assembly

Across TCGA cell cohorts, RNA activity of the Apical junction assembly pathway is significantly associated with the protein abundance of multiple proteins, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP4, VCL, and MYL6, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Apical junction assembly activity versus MAP4 in URINARY_TRACT (Pearson r = 0.77).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	MAP4 →	+2.347	+0.285	<.001	.001	3	13
BLOOD_Lymphoma	VCL →	+1.899	+0.228	<.001	<.001	3	13
BONE	MYL6 →	+1.497	+0.180	<.001	.002	3	13
OESOPHAGUS	SEPTIN7 →	+1.011	+0.342	<.001	.001	3	12
LUNG_NSCLC_LUSC	PDCD6IP →	+1.368	+0.331	.006	<.001	2	12
URINARY_TRACT	PAK2 →	+2.191	+0.351	.003	.002	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043297 vs MAP4 — URINARY_TRACT

Explore this scatter interactively →