Anoikis

Across TCGA patient cohorts, RNA activity of the Anoikis pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL5, CMIP_S349, and RPL27A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Anoikis activity versus RPL5 in OV (Pearson r = -0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RPL5 →	-0.207	-0.045	<.001	<.001	3	7
HNSC	CMIP_S349 →	-0.810	-0.076	<.001	<.001	3	6
PDAC	RPL27A →	-0.303	-0.031	.001	.001	3	6
OV	AKAP12_S612 →	+1.213	+0.064	<.001	<.001	3	6
OV	KANK2_S540 →	+0.693	+0.045	.002	.003	3	6
OV	PLAC9 →	+0.921	+0.045	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043276 vs RPL5 — OV

Explore this scatter interactively →