Negative regulation of monoatomic ion transport

Across TCGA patient cohorts, RNA activity of the Negative regulation of monoatomic ion transport pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DIAPH3, PIP5K1A, and SMG7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of monoatomic ion transport activity versus DIAPH3 in BRCA (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DIAPH3 →	-0.568	-0.160	.001	<.001	3	6
UCEC	PIP5K1A →	-0.433	-0.182	<.001	<.001	3	5
HNSC	SMG7 →	-0.491	-0.179	.002	.001	3	4
HNSC	SOX9 →	-0.653	-0.183	.008	.001	2	5
HNSC	SETP14 →	-0.700	-0.211	.007	.004	3	4
HNSC	PRC1-AS1 →	-0.513	-0.229	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043271 vs DIAPH3 — BRCA

Explore this scatter interactively →