Negative regulation of monoatomic ion transport

Across TCGA cell cohorts, RNA activity of the Negative regulation of monoatomic ion transport pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SERINC1, MORN2, and BBIP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of monoatomic ion transport activity versus SERINC1 in OESOPHAGUS (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SERINC1 →	+1.035	+0.277	<.001	<.001	3	5
LARGE_INTESTINE	MORN2 →	+1.026	+0.204	.001	.007	3	5
OESOPHAGUS	BBIP1 →	+0.660	+0.207	<.001	.002	3	5
SKIN	RTN4 →	+0.617	+0.134	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	NFU1 →	+0.884	+0.256	<.001	.001	3	5
UPPER_AERODIGESTIVE_TRACT	GNG10 →	+1.014	+0.224	.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043271 vs SERINC1 — OESOPHAGUS

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