Positive regulation of monoatomic ion transport

Across TCGA patient cohorts, RNA activity of the Positive regulation of monoatomic ion transport pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VWA5A, FOXP1, and CLCA2, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of monoatomic ion transport activity versus VWA5A in BRCA (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	VWA5A →	+0.967	+0.221	<.001	.004	3	2
BRCA	FOXP1 →	+0.599	+0.206	<.001	.007	3	2
BRCA	CLCA2 →	+3.481	+0.373	.004	.007	3	2
OV	SFRP2 →	+4.034	+0.262	<.001	.001	3	2
BRCA	ZNF385C →	-0.756	-0.288	.003	.009	3	2
OV	PARVA →	+0.900	+0.258	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043270 vs VWA5A — BRCA

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