Positive regulation of monoatomic ion transport

Across TCGA patient cohorts, RNA activity of the Positive regulation of monoatomic ion transport pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SCARF2_S653, TAGLN, and UGDH, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of monoatomic ion transport activity versus SCARF2_S653 in OV (Pearson r = 0.57).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SCARF2_S653 →	+0.750	+0.240	<.001	<.001	3	2
OV	TAGLN →	+1.402	+0.211	<.001	.004	3	2
COAD	UGDH →	+1.117	+2.717	<.001	<.001	3	2
OV	VCL →	+0.668	+0.319	<.001	<.001	3	2
OV	C1R →	+0.862	+0.281	<.001	<.001	3	2
OV	CAVIN3_S56 →	+1.365	+0.296	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043270 vs SCARF2_S653 — OV

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