Positive regulation of monoatomic ion transport

Across TCGA cell cohorts, RNA activity of the Positive regulation of monoatomic ion transport pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LANCL2, RAMP3, and PRDM12, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LANCL2 grouped by Positive regulation of monoatomic ion transport-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	LANCL2 →	-0.222	-1.275	<.001	<.001	3	6
OVARY	RAMP3 →	-0.278	-1.163	<.001	.001	3	5
SOFT_TISSUE	PRDM12 →	-0.212	-0.778	<.001	.004	3	5
SOFT_TISSUE	RAB21 →	-0.272	-0.729	.002	.009	2	6
OVARY	PMM1 →	-0.356	-1.116	<.001	<.001	3	5
LARGE_INTESTINE	RNF130 →	-0.107	-0.385	.004	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LANCL2 by Positive regulation of monoatomic ion transport activity — OVARY

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