Positive regulation of potassium ion transport

Across TCGA patient cohorts, RNA activity of the Positive regulation of potassium ion transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SUPT6H, SNRNP200, and CPSF1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of potassium ion transport activity versus SUPT6H in LSCC (Pearson r = -0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SUPT6H →	-0.278	-0.058	<.001	<.001	3	6
LSCC	SNRNP200 →	-0.228	-0.057	<.001	<.001	3	6
GBM	CPSF1 →	-0.245	-0.064	<.001	<.001	3	6
LSCC	CSTF3 →	-0.194	-0.039	<.001	.002	3	6
GBM	DDX46 →	-0.170	-0.040	.002	.001	3	6
GBM	SF3A2 →	-0.210	-0.042	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043268 vs SUPT6H — LSCC

Explore this scatter interactively →