Positive regulation of potassium ion transport

Across TCGA patient cohorts, RNA activity of the Positive regulation of potassium ion transport pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DACT3, CNRIP1, and SRPX, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of potassium ion transport activity versus DACT3 in BRCA (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DACT3 →	+0.732	+0.895	<.001	<.001	3	8
BRCA	CNRIP1 →	+0.795	+0.741	<.001	<.001	3	8
BRCA	SRPX →	+0.804	+0.521	<.001	<.001	3	8
LSCC	CSRP1 →	+0.580	+0.825	<.001	<.001	3	8
BRCA	NAP1L3 →	+0.772	+0.751	<.001	<.001	3	8
OV	ACTA2 →	+1.872	+1.013	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043268 vs DACT3 — BRCA

Explore this scatter interactively →