Positive regulation of potassium ion transport

Across TCGA cell cohorts, RNA activity of the Positive regulation of potassium ion transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLEC, ZNF185, and TMSB10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLEC grouped by Positive regulation of potassium ion transport-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PLEC →	-1.980	-1.372	.005	.001	3	5
LUNG_NSCLC_LUSC	ZNF185 →	-3.078	-1.470	<.001	<.001	3	4
LUNG_SCLC	TMSB10 →	-1.415	-1.219	.007	<.001	3	4
CNS	PI4K2A →	-0.443	-0.939	.001	<.001	3	4
BLOOD_Myeloma	N4BP2L1 →	+1.116	+1.450	.006	<.001	3	4
LUNG_NSCLC_LUSC	SLC41A2 →	-1.693	-1.329	.004	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLEC by Positive regulation of potassium ion transport activity — LUNG_SCLC

Explore this box plot interactively →