Positive regulation of potassium ion transport

Across TCGA cell cohorts, RNA activity of the Positive regulation of potassium ion transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SH3RF2, FLNA, and ACTN4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of potassium ion transport activity versus SH3RF2 in LUNG_NSCLC_LUAD (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SH3RF2 →	+2.017	+0.254	<.001	<.001	3	7
KIDNEY	FLNA →	+1.830	+0.218	.003	.002	3	6
BLOOD_Lymphoma	ACTN4 →	+1.442	+0.259	<.001	.003	2	7
SOFT_TISSUE	RAC2 →	+4.008	+0.250	.002	.006	3	5
SKIN	EPSTI1 →	+1.040	+0.152	.008	.001	3	5
SKIN	MX1 →	+2.254	+0.218	.006	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043268 vs SH3RF2 — LUNG_NSCLC_LUAD

Explore this scatter interactively →