Negative regulation of potassium ion transport

Across TCGA patient cohorts, RNA activity of the Negative regulation of potassium ion transport pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TGFB1I1_S403, CAVIN3, and PRKG1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of potassium ion transport activity versus TGFB1I1_S403 in BRCA (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TGFB1I1_S403 →	+0.603	+0.032	<.001	<.001	3	6
BRCA	CAVIN3 →	+0.755	+0.034	.001	.001	3	6
CCRCC	PRKG1 →	+0.574	+0.068	<.001	<.001	3	6
BRCA	GTPBP4 →	-0.570	-0.041	<.001	<.001	3	5
OV	NOS3_S114 →	+0.953	+0.050	<.001	<.001	3	5
HNSC	RTN4 →	+0.283	+0.035	<.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043267 vs TGFB1I1_S403 — BRCA

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