Negative regulation of potassium ion transport

Across TCGA cell cohorts, RNA activity of the Negative regulation of potassium ion transport pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGA3, FOSL1, and NT5E, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of potassium ion transport activity versus ITGA3 in LIVER (Pearson r = 0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ITGA3 →	+5.090	+0.587	<.001	.001	3	9
BREAST	FOSL1 →	+5.178	+0.468	<.001	<.001	3	8
SOFT_TISSUE	NT5E →	+7.057	+0.624	<.001	.002	3	7
SOFT_TISSUE	NIBAN1 →	+3.701	+0.510	.001	.003	3	7
BREAST	PLAU →	+4.266	+0.462	<.001	<.001	3	7
SKIN	TGFBI →	+4.937	+0.742	<.001	.006	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043267 vs ITGA3 — LIVER

Explore this scatter interactively →