Regulation of potassium ion transport

Across TCGA patient cohorts, RNA activity of the Regulation of potassium ion transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SNRNP200, EFTUD2, and SMCHD1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of potassium ion transport activity versus SNRNP200 in LSCC (Pearson r = -0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SNRNP200 →	-0.215	-0.035	<.001	<.001	3	7
BRCA	EFTUD2 →	-0.161	-0.017	.008	.005	3	7
BRCA	SMCHD1 →	-0.327	-0.020	.001	<.001	3	7
UCEC	TK1 →	-0.439	-0.031	<.001	<.001	3	7
UCEC	MED24 →	-0.186	-0.042	<.001	<.001	3	7
LSCC	EIF4A3 →	-0.205	-0.029	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043266 vs SNRNP200 — LSCC

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