Regulation of potassium ion transport

Across TCGA cell cohorts, RNA activity of the Regulation of potassium ion transport pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIM22, IL15, and CCZ1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRIM22 grouped by Regulation of potassium ion transport-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TRIM22 →	-2.630	-1.041	<.001	<.001	3	4
CNS	IL15 →	-0.895	-1.014	.003	<.001	3	4
URINARY_TRACT	CCZ1 →	-0.667	-1.732	.006	<.001	3	4
LIVER	DENND3 →	-1.423	-1.346	.009	<.001	3	3
SOFT_TISSUE	PLXNC1 →	+2.212	+1.011	.001	.005	3	3
PANCREAS	F3 →	-2.638	-0.711	.005	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRIM22 by Regulation of potassium ion transport activity — CNS

Explore this box plot interactively →