Regulation of potassium ion transport

Across TCGA cell cohorts, RNA activity of the Regulation of potassium ion transport pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNTA1, FYN, and RUNX1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of potassium ion transport activity versus SNTA1 in URINARY_TRACT (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	SNTA1 →	+1.436	+0.389	.001	.001	3	6
LUNG_NSCLC_LUSC	FYN →	+2.905	+0.203	.003	.002	3	5
LIVER	RUNX1 →	+2.724	+0.292	<.001	.006	3	5
SOFT_TISSUE	SYNJ2 →	+1.770	+0.363	<.001	.003	3	5
LIVER	SNAPC1 →	+2.367	+0.411	.002	.004	2	6
BREAST	PASK →	-0.930	-0.260	.008	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043266 vs SNTA1 — URINARY_TRACT

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