Regulation of carbohydrate biosynthetic process

Across TCGA patient cohorts, RNA activity of the Regulation of carbohydrate biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN8, LARP4_S583, and CHAF1B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of carbohydrate biosynthetic process activity versus SEPTIN8 in GBM (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SEPTIN8 →	+0.211	+0.020	.003	.007	3	7
PDAC	LARP4_S583 →	-0.362	-0.022	.001	<.001	3	6
GBM	CHAF1B →	-0.484	-0.038	.001	<.001	3	6
BRCA	KPNA2 →	-0.473	-0.018	.002	.008	3	6
BRCA	RIF1_S782 →	-0.840	-0.023	<.001	.003	3	5
BRCA	RRM2 →	-0.437	-0.020	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043255 vs SEPTIN8 — GBM

Explore this scatter interactively →