Erythrocyte maturation

Across TCGA patient cohorts, RNA activity of the Erythrocyte maturation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GINS1, MMRN1, and SYNE3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Erythrocyte maturation activity versus GINS1 in UCEC (Pearson r = 0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GINS1 →	+0.627	+0.411	<.001	<.001	3	4
OV	MMRN1 →	-0.936	-0.210	.001	.001	3	4
HNSC	SYNE3 →	-0.492	-0.447	.002	.003	3	4
GBM	KIF20A →	+0.762	+0.594	.005	.002	3	4
UCEC	PTGFR →	-0.664	-0.298	.006	.009	3	4
UCEC	CSE1L →	+0.652	+0.469	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043249 vs GINS1 — UCEC

Explore this scatter interactively →