Erythrocyte maturation

Across TCGA cell cohorts, RNA activity of the Erythrocyte maturation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CENPV, METTL7A, and PPARD, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CENPV grouped by Erythrocyte maturation-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CENPV →	+1.412	+0.781	.004	<.001	3	4
OESOPHAGUS	METTL7A →	-2.448	-0.954	.007	.009	3	4
PANCREAS	PPARD →	-1.065	-1.133	.004	.002	3	4
BONE	MAST1 →	+2.722	+0.373	.002	<.001	3	4
BONE	FCHO1 →	+1.402	+0.312	.001	.001	3	4
OVARY	CEBPD →	-1.540	-1.252	.003	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CENPV by Erythrocyte maturation activity — CNS

Explore this box plot interactively →