Erythrocyte maturation

Across TCGA cell cohorts, RNA activity of the Erythrocyte maturation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are G6PD, AKR1B10, and GCLC, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Erythrocyte maturation activity versus G6PD in BONE (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	G6PD →	+1.802	+1.409	.006	.002	3	11
LUNG_NSCLC_LUAD	AKR1B10 →	+4.696	+0.770	<.001	<.001	3	6
LUNG_NSCLC_LUAD	GCLC →	+1.268	+0.728	<.001	<.001	3	5
BONE	NSMCE4A →	+0.729	+1.609	<.001	<.001	3	4
LUNG_NSCLC_LUAD	AKR1C2 →	+5.915	+0.849	<.001	<.001	3	4
BREAST	UBL4A →	+1.167	+0.799	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043249 vs G6PD — BONE

Explore this scatter interactively →